Peptidus Biotech

Peptídeos contra vícios? Sim, é possível. Um novo artigo da Nature Biotechnology mostra que agonistas do receptor GLP-1, como peptídeos, podem reduzir comportamentos compulsivos associados ao álcool, tabaco e outras substâncias. Este estudo utilizou o peptídeo bydureon (exenatide), outro agonista injetável do GLP-1 para diabetes tipo 2 produzido pela AstraZeneca makes. Essas moléculas prometem revolucionar o tratamento de vícios, além de já serem usadas contra obesidade e diabetes. Na Peptidus Biotech , desenvolvemos peptídeos multifuncionais com potencial para transformar a saúde humana e animal, atuando não apenas como antimicrobianos, mas também como moduladores metabólicos e comportamentais. Inovação com propósito para um futuro mais saudável. Peptides against addiction? Yes, it's possible. A new Nature Biotechnology article reveals that GLP-1 receptor agonists, such as peptide-based drugs, may help reduce compulsive behaviours linked to alcohol, tobacco, and other addictions. The study used the peptide bydureon (exenatide), another injectable GLP-1 agonist prescribed for type 2 diabetes, which AstraZeneca makes. These molecules could redefine how we treat dependence, building on their success in obesity and diabetes. At Peptidus Biotech , we are committed to deg multifunctional peptides beyond antimicrobial action to metabolic and behavioural health. Science and purpose unite for a healthier future.

Unlocking the Power of Bioinspiration: A New Frontier for Animal Health The rich biomes of South America are treasure troves of biodiversity, offering unparalleled opportunities for bioinspiration. At Peptidus Biotech, we are harnessing this potential by combining cutting-edge AI with the incredible molecular diversity in these ecosystems to revolutionize animal health. Initially, machine-learning models relied on large protein repositories such as UniProt for structure prediction. Today, tools like AlphaFold 2, BAse camp, RoseTTAFold, ESMFold, OpenFold, and SWISS-MODEL have expanded the protein universe, enabling us to explore nature’s diversity like never before. However, mining nature’s solutions have historically been challenging. While early biotech successes relied on natural components like DNA polymerases and restriction enzymes, commercialization often overlooked equitable benefit-sharing with all stakeholders. A recent article in Nature Biotechnology https://lnkd.in/g-EPitx2 highlights the transformative power of bioinspiration and the importance of ethical, benefit-sharing collaborations with Indigenous communities. As a Brazilian AI-driven biotech, we are proud to be at the forefront of this movement, leveraging our unique position to explore and develop innovative, nature-inspired solutions while ensuring fair partnerships and sustainable practices. Together, we can create a future where technology and nature work hand in hand to improve animal health and well-being. #bioinspiration #biodiversity #AI #animalhealth #peptidus #brazil #biotech #sustainability #naturebiotechnology #peptidedesign

Unlocking the Power of Bioinspiration: A New Frontier for Animal Health The rich biomes of South America are treasure troves of biodiversity, offering unparalleled opportunities for bioinspiration. At Peptidus Biotech, we are harnessing this potential by combining cutting-edge AI with the incredible molecular diversity in these ecosystems to revolutionize animal health. Initially, machine-learning models relied on large protein repositories such as UniProt for structure prediction. Today, tools like AlphaFold 2, BAse camp, RoseTTAFold, ESMFold, OpenFold, and SWISS-MODEL have expanded the protein universe, enabling us to explore nature’s diversity like never before. However, mining nature’s solutions have historically been challenging. While early biotech successes relied on natural components like DNA polymerases and restriction enzymes, commercialization often overlooked equitable benefit-sharing with all stakeholders. A recent article in Nature Biotechnology https://lnkd.in/g-EPitx2 highlights the transformative power of bioinspiration and the importance of ethical, benefit-sharing collaborations with Indigenous communities. As a Brazilian AI-driven biotech, we are proud to be at the forefront of this movement, leveraging our unique position to explore and develop innovative, nature-inspired solutions while ensuring fair partnerships and sustainable practices. Together, we can create a future where technology and nature work hand in hand to improve animal health and well-being. #bioinspiration #biodiversity #AI #animalhealth #peptidus #brazil #biotech #sustainability #naturebiotechnology #peptidedesign

A Breakthrough in Chronic Pain Treatment Without the Risks using AI compound design Over 1 billion people suffer from chronic pain worldwide, often relying on opioids with severe risks of addiction and overdose. But a breakthrough offers hope. Researchers from Stanford University and Washington University School of Medicine have developed a novel compound that targets the CB1 receptor completely new. Unlike previous approaches, which caused psychoactive side effects and loss of efficacy, this new strategy involved rational drug design using advanced computational simulations. By mapping the dynamic structural changes of the CB1 receptor, researchers discovered a previously unknown cryptic pocket—a transient binding site that was not detected in experimental studies. They designed a compound that selectively binds to this pocket using AI-driven molecular modeling, activating only the pain-relief pathway without triggering psychoactive effects or tolerance buildup. This innovation marks a paradigm shift in drug discovery, demonstrating how computational approaches can lead to safer, more effective treatments for chronic pain. #chroniain #drugdiscovery #computationalbiology #painmanagement #peptides https://lnkd.in/dFqH37vr   Um Avanço no Tratamento da Dor Crônica Sem Riscos usando design de compostos via IA Mais de 1 bilhão de pessoas sofrem de dor crônica no mundo, muitas vezes dependentes de opioides com alto risco de vício e overdose. Mas uma nova descoberta traz esperança. Pesquisadores da Stanford University e da Washington University School of Medicine desenvolveram um composto inovador que interage com o receptor CB1 de forma totalmente nova. Diferente das abordagens anteriores, que geravam efeitos psicoativos indesejados e perda de eficácia, essa nova estratégia utilizou design racional de fármacos com simulações computacionais avançadas. Ao mapear as mudanças estruturais dinâmicas do receptor CB1, os pesquisadores descobriram um bolso críptico inédito—um sítio de ligação transitório que não havia sido detectado em estudos experimentais. Com o auxílio de modelagem molecular baseada em IA, eles projetaram um composto que se liga seletivamente a esse bolso, ativando apenas a via de alívio da dor sem causar efeitos psicoativos ou perda de eficácia ao longo do tempo. Essa inovação representa uma mudança de paradigma na descoberta de fármacos, demonstrando como abordagens computacionais podem levar a tratamentos mais seguros e eficazes para a dor crônica. https://lnkd.in/dFqH37vr

Next week, we'll be landing in Paris for Hello Tomorrow and its various side events, including the one at the beautiful Brazilian Embassy. Let’s meet there!

Peptidus and the AI-Driven Protein Design Revolution: Safe and Sustainable Innovation Peptidus Biotech is at the forefront of developing potent and selective peptides, with a strong focus on safety and specificity, while ensuring minimal environmental impact and consumer protection. The rapid advancement of computational protein design, particularly with the aid of artificial intelligence, is unlocking new and exciting possibilities in medicine and sustainability. This revolution, while presenting biosecurity challenges, also offers a promising future. One key proposal to address these challenges is the secure logging of synthetic genetic sequences, enabling emergency tracking without hindering innovation. The global standardization of these practices could be essential to ensuring that AI-driven protein design remains both safe and effective. In this editorial by renowned researchers David Baker and George Church, published in the prestigious journal Science Magazine, the importance of balancing security with scientific progress was clearly emphasized, highlighting the need for collaboration between academia, industry, and policymakers. Peptidus fully s all biosecurity practices to ensure our products are incredibly safe and highly effective. #ProteinDesign #AIinBiotech #Biosecurity #SyntheticBiology #ScienceInnovation https://lnkd.in/drERKnT4 🇧🇷 A Peptidus Biotech está na vanguarda do desenvolvimento de peptídeos potentes e seletivos, com um forte foco na segurança e especificidade, garantindo ao mesmo tempo um impacto ambiental mínimo e a proteção do consumidor. O rápido avanço do design computacional de proteínas, especialmente com o auxílio da inteligência artificial, está desbloqueando novas e empolgantes possibilidades na medicina e na sustentabilidade. Essa revolução, embora apresente desafios de biossegurança, também oferece um futuro promissor. Uma proposta-chave para enfrentar esses desafios é o registro seguro de sequências genéticas sintéticas, permitindo o rastreamento emergencial sem prejudicar a inovação. A padronização global dessas práticas pode ser essencial para garantir que o design de proteínas impulsionado pela IA permaneça seguro e eficaz. Neste editorial dos renomados pesquisadores David Baker e George Church, publicado na prestigiosa revista Science, a importância de equilibrar segurança e progresso científico foi claramente enfatizada, destacando a necessidade de colaboração entre a academia, a indústria e os formuladores de políticas. A Peptidus apoia plenamente todas as práticas de biossegurança para garantir que nossos produtos sejam extremamente seguros e altamente eficazes. https://lnkd.in/drERKnT4 #DesignDeProteínas #IAnaBiotecnologia #Biossegurança #BiologiaSintética #InovaçãoCientífica

Já imaginou melhorar o bem-estar do seu pet com terapias mais saudáveis e eficientes? 🐾 A Peptidus Biotech está revolucionando a saúde animal com terapias à base de peptídeos, substituindo o uso de antibióticos em pets e animais de produção. Quer conhecer essa e outras inovações que estão transformando o mercado? Nos vemos no Deep Tech Summit, dias 12 e 13 de novembro, no Complexo Inova USP. Garanta seu lugar: https://lnkd.in/dYpY-H4z #DeepTechSummit #conexoes #networking